Comprehensive review of targeted therapy for colorectal cancer

YH Xie, YX Chen, JY Fang - Signal transduction and targeted therapy, 2020 - nature.com
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Biodegradable polymers and constructs: A novel approach in drug delivery

SK Prajapati, A Jain, A Jain, S Jain - European polymer journal, 2019 - Elsevier
New polymers are continuously developed for new therapeutic applications. New and
modified polymer chemistries that offer distinctive degradation and drug delivery are being …

Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments

R Abedizadeh, F Majidi, HR Khorasani, H Abedi… - Cancer and Metastasis …, 2024 - Springer
Colorectal cancer is the third most common and the second deadliest cancer worldwide. To
date, colorectal cancer becomes one of the most important challenges of the health system …

Signaling pathways involved in colorectal cancer progression

Z Koveitypour, F Panahi, M Vakilian, M Peymani… - Cell & bioscience, 2019 - Springer
Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality.
Different molecular mechanisms have been attributed to the development and progress of …

Emerging trends in colorectal cancer: Dysregulated signaling pathways

R Ahmad, JK Singh, A Wunnava… - International …, 2021 - spandidos-publications.com
Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer-related mortality globally. The American Cancer Society …

Molecular network of colorectal cancer and current therapeutic options

Z Huang, M Yang - Frontiers in oncology, 2022 - frontiersin.org
Colorectal cancer (CRC), a leading cause of cancer-related mortalities globally, results from
the accumulation of multiple genetic and epigenetic alterations in the normal colonic and …

Colorectal cancer: Genetic alterations, novel biomarkers, current therapeutic strategies and clinical trials

M Housini, B Dariya, N Ahmed, A Stevens, H Fiadjoe… - Gene, 2024 - Elsevier
Colorectal cancer (CRC) is the third most commonly detected cancer with a serious global
health issue. The rates for incidence and mortality for CRC are alarming, especially since …

Tumor-immune profiling of CT-26 and Colon 26 syngeneic mouse models reveals mechanism of anti-PD-1 response

Y Sato, Y Fu, H Liu, MY Lee, MH Shaw - BMC cancer, 2021 - Springer
Background Immune checkpoint blockade (ICB) therapies have changed the paradigm of
cancer therapies. However, anti-tumor response of the ICB is insufficient for many patients …

Autophagy and the insulin-like growth factor (IGF) system in colonic cells: implications for colorectal neoplasia

A Kasprzak - International journal of molecular sciences, 2023 - mdpi.com
Colorectal cancer (CRC) is one of the most common human malignancies worldwide. Along
with apoptosis and inflammation, autophagy is one of three important mechanisms in CRC …

Microfluidic‐assisted production of gastro‐resistant active‐targeted diatomite nanoparticles for the local release of galunisertib in metastatic colorectal cancer cells

C Tramontano, JP Martins, L De Stefano… - Advanced …, 2023 - Wiley Online Library
The oral route is highly desirable for colorectal cancer (CRC) treatment because it allows
concentrating the drug in the colon and achieving a localized effect. However, orally …