General anaesthesia is usually considered to safely induce a reversible brain state allowing
the performance of surgery under optimal conditions. An increasing number of clinical and …

The field of lipidomics, as coined in 2003, has made profound advances and been rapidly
expanded. The mass spectrometry-based strategies of this analytical methodology-oriented …

A potential cause of suffering in animal experimentation is pain induced by procedures,
diseases, and injuries. Pain is not only nociception, the sensory nervous system's response …

Thousands of infants and children undergo complicated surgical procedures that require
prolonged periods of anesthesia and/or sedation each year. A growing body of preclinical …

Multi-dimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) has made
profound advances for comprehensive analysis of cellular lipids. It represents one of the …

Preclinical evidence suggests that anesthetic agents harm the developing brain thereby
causing long‐term neurocognitive impairments. It is not clear if these findings apply to …

Background: Recent studies in various animal models have suggested that anesthetics such
as propofol, when administered early in life, can lead to neurotoxicity. These studies have …

Sevoflurane is a volatile anesthetic that has been widely used in general anesthesia, yet its
safety in pediatric use is a public concern. This study sought to evaluate whether prolonged …

It has been reported that sevoflurane induces neurotoxicity in the developing brain.
Dexmedetomidine is an α2 adrenoceptor agonist used for the prevention of sevoflurane …

Background Recently, the safety of repeated and lengthy anesthesia administration has
been called into question, a subset of these animal studies demonstrated that anesthetics …