Vibrational spectroscopy is an essential tool in chemical analyses, biological assays, and
studies of functional materials. Over the past decade, various coherent nonlinear vibrational …

RNAs exhibit a plethora of functions far beyond transmitting genetic information. Often, RNA
functions are entailed in their structure, be it as a regulatory switch, protein binding site, or …

Monitoring the site-specific local structure and dynamics of polynucleotides and DNA is
important for understanding their biological functions. However, structurally characterizing …

The structure and dynamics of polyanionic biomolecules, like RNA, are decisively
determined by their electric interactions with the water molecules and the counterions in the …

Time-resolved temperature-jump/drop infrared (IR) spectroscopy has been used to measure
the impact of stem base sequence on the melting and refolding dynamics of ribonucleic acid …

Carbohydrates constitute one of the four key classes of biomacromolecules but have not
been studied by 2D-IR spectroscopy so far. Similarly as for proteins, a lack of native …

Proteins function as ensembles of interconverting structures. The motions span from
picosecond bond rotations to millisecond and longer subunit displacements …

The interaction of phosphate groups with ions in an aqueous environment has a strong
impact on the structure and folding processes of DNA and RNA. The dynamic variety of ionic …

Determining the structural dynamics of RNA and DNA is essential to understanding their
cellular function, but direct measurement of strand association or folding remains …

Electric interactions between ions and ionic molecular groups in aqueous solution play a
fundamental role in chemistry and biology. While Mg2+ ions are known to strongly affect the …