Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

The process of translation requires substantial cellular resources. Cells have therefore
evolved complex mechanisms to control overall protein synthesis as well as the translation …

Long ignored as a vestigial remnant of cytokinesis, the mammalian midbody (MB) is
released post-abscission inside large extracellular vesicles called MB remnants (MBRs) …

Protein kinase RNA-activated (PKR) induces immune response by sensing viral double-
stranded RNAs (dsRNAs). However, growing evidence suggests that PKR can also be …

The highly conserved 14-3-3 protein family has risen to a position of importance in cell
biology owing to its involvement in vital cellular processes, such as metabolism, protein …

The link between perturbations in translational control and cancer etiology is becoming a
primary focus in cancer research. It has now been established that genetic alterations in …

The Myc oncogene regulates the expression of several components of the protein synthetic
machinery, including ribosomal proteins, initiation factors of translation, RNA polymerase III …

Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells.
Following genotoxic stress, diverse molecular signals must be integrated to establish …