Background There are a number of instruments that describe severity and progression of
multiple sclerosis and they are increasingly used as endpoints to assess the effectiveness of …

Abstract The Paced Auditory Serial Addition Test (PASAT)[Gronwall, D., & Sampson,
H.(1974). The psychological effects of concussion. Auckland, New Zealand: Auckland …

Radiological images have been assessed qualitatively in most clinical settings by the expert
eyes of radiologists and other clinicians. On the other hand, quantification of radiological …

Background Clinical studies suggested that fampridine (4-aminopyridine) improves motor
function in people with multiple sclerosis. This phase III study assessed efficacy and safety of …

Background: Interferon β-1a (IFNβ-1a, Avonex) is efficacious in relapsing forms of MS.
Studies of other IFNβ preparations in secondary progressive MS (SPMS) yielded conflicting …

The Timed 25-Foot Walk is under evaluation as a clinical tool to follow patients with MS.
Several approaches have been taken to define a clinically significant change in this …

OBJECTIVES: The aim of this study was to assess the motor function of upper extremity and
its relation with fatigue, cognitive function and quality of life in Multiple Sclerosis (MS) …

With the advent and widespread use of partially effective disease modifying drug therapies
for multiple sclerosis (MS), future clinical trials will undoubtedly test experimental …

Objective: In this study, we used data from clinical trials of dalfampridine (fampridine outside
the United States) to re-examine the clinical meaningfulness of Timed 25-Foot Walk …

Objective: To determine the longitudinal metric properties of recently developed clinical
assessment tools in spinocerebellar ataxia (SCA). Methods: A subset of 171 patients from …