Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …

Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

Abstract Genome‐, transcriptome‐and proteome‐wide measurements provide insights into
how biological systems are regulated. However, fundamental aspects relating to which …

Reproducibility in research can be compromised by both biological and technical variation,
but most of the focus is on removing the latter. Here we investigate the effects of biological …

Abstract The Human Proteome Organization (HUPO) launched the Human Proteome Project
(HPP) in 2010, creating an international framework for global collaboration, data sharing …

Regulation of mRNA translation offers the opportunity to diversify the expression and
abundance of proteins made from individual gene products in cells, tissues and organisms …

Human blood plasma provides a highly accessible window to the proteome of any individual
in health and disease. Since its inception in 2002, the Human Proteome Organization's …

Assigning functions to the vast array of proteins present in eukaryotic cells remains
challenging. To identify relationships between proteins, and thereby enable functional …

Osteoarthritis causes pain and functional disability for over 500 million people worldwide. To
develop disease-stratifying tools and modifying therapies, we need a better understanding …

Background Immunotherapy against solid tumors has long been hampered by the
development of immunosuppressive tumor microenvironment, and the lack of a specific …