Vigorous transport of cytoplasmic components along axons over substantial distances is
crucial for the maintenance of neuron structure and function. The transport of mitochondria …

Adult-onset neurodegenerative disorders are disabling and often fatal diseases of the
nervous system whose underlying mechanisms of cell death remain unknown. Defects in …

The production of neurons from neural progenitor cells, the growth of axons and dendrites
and the formation and reorganization of synapses are examples of neuroplasticity. These …

Mitochondrial dysfunction has been described as an early pathological mechanism
delineating the selective neurodegeneration that occurs in Huntington's disease (HD), a …

The inter-neuronal communication occurring in extensively branched neuronal cells is
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …

Mitochondrial shape is determined by fission and fusion reactions, perturbation of which can
contribute to neuronal injury and disease. Mitochondrial fission is catalyzed by dynamin …

Aging is a complex feature and involves loss of multiple functions and nonreversible
phenotypes. However, several studies suggest it is possible to protect against aging and …

Intense research on the pathogenesis of Huntington's disease (HD), a genetic
neurodegenerative disease caused by a polyglutamine expansion in the Huntingtin (Htt) …

The dynamic properties of mitochondria (mitochondrial fission, fusion, transport biogenesis
and degradation) are critical for neuronal function and health, and dysregulation of …

The morphology of a population of mitochondria is the result of several interacting dynamical
phenomena, including fission, fusion, movement, elimination and biogenesis. Each of these …