Small molecules in the treatment of COVID-19
S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
Amentoflavone derivatives significantly act towards the main protease (3CLPRO/MPRO) of SARS-CoV-2: in silico admet profiling, molecular docking, molecular …
SARS-CoV-2 is the foremost culprit of the novel coronavirus disease 2019 (nCoV-19 and/or
simply COVID-19) and poses a threat to the continued life of humans on the planet and …
simply COVID-19) and poses a threat to the continued life of humans on the planet and …
Antimalarial drug discovery against malaria parasites through haplopine modification: an advanced computational approach
The widespread emergence of antimalarial drug resistance has created a major threat to
public health. Malaria is a life‐threatening infectious disease caused by Plasmodium spp …
public health. Malaria is a life‐threatening infectious disease caused by Plasmodium spp …
[HTML][HTML] Target specificity of selective bioactive compounds in blocking α-dystroglycan receptor to suppress Lassa virus infection: an in silico approach
Lassa hemorrhagic fever, caused by Lassa mammarenavirus (LASV) infection, accumulates
up to 5000 deaths every year. Currently, there is no vaccine available to combat this …
up to 5000 deaths every year. Currently, there is no vaccine available to combat this …
Oncoinformatic screening of the gene clusters involved in the HER2-positive breast cancer formation along with the in silico pharmacodynamic profiling of selective …
The HER2-positive patients occupy~ 30% of the total breast cancer patients globally where
no prevalent drugs are available to mitigate the frequent metastasis clinically except …
no prevalent drugs are available to mitigate the frequent metastasis clinically except …
[HTML][HTML] Point-specific interactions of isovitexin with the neighboring amino acid residues of the hACE2 receptor as a targeted therapeutic agent in suppressing the …
Objective: Despite the development of several vaccines against severe acute respiratory
syndrome coronavirus-2, the need for an additional prophylactic agent is evident. In recent …
syndrome coronavirus-2, the need for an additional prophylactic agent is evident. In recent …
Natural flavonoids effectively block the CD81 receptor of hepatocytes and inhibit HCV infection: A computational drug development approach
Hepatitis C virus (HCV) infection is a major public health concern, and almost two million
people are infected per year globally. This is occurred by the diverse spectrum of viral …
people are infected per year globally. This is occurred by the diverse spectrum of viral …
An in-silico identification of potential flavonoids against kidney fibrosis targeting TGFβR-1
Fibrosis is a hallmark of progressive kidney diseases. The overexpression of profibrotic
cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and …
cytokine, namely transforming growth factor β (TGF-β) due to excessive inflammation and …
[HTML][HTML] Catabolic profiling of selective enzymes in the saccharification of non-food lignocellulose parts of biomass into functional edible sugars and bioenergy: An in …
Objectives: The research aims to analyze the catabolic strength of different hydrolytic
enzymes in assessing the biological conversion potential of lignocellulose parts of …
enzymes in assessing the biological conversion potential of lignocellulose parts of …
In silico analysis of the apoptotic and HPV inhibitory roles of some selected phytochemicals detected from the rhizomes of greater cardamom
Occurrence of cervical cancer, caused due to persistent human papilloma virus (HPV)
infection, is common in women of developing countries. As the conventional treatments are …
infection, is common in women of developing countries. As the conventional treatments are …