[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease

K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Species-specific temperature sensitivity of TRPA1

WJ Laursen, EO Anderson, LJ Hoffstaetter… - Temperature, 2015 - Taylor & Francis
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal ion channel sensitive to
temperature and chemical stimuli. The importance of temperature and aversive chemical …

[HTML][HTML] Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Y Wang, L Cao, CY Lee, T Matsuo, K Wu… - Nature …, 2018 - nature.com
Innate behaviors are genetically encoded, but their underlying molecular mechanisms
remain largely unknown. Predator odor 2, 4, 5-trimethyl-3-thiazoline (TMT) and its potent …

The physiological role of TRP channels in sleep and circadian rhythm

GE Woodard, JA Rosado, H Li - Journal of Cellular and …, 2024 - Wiley Online Library
TRP channels, are non‐specific cationic channels that are involved in multiple physiological
processes that include salivation, cellular secretions, memory extinction and consolidation …

Odour-induced analgesia mediated by hypothalamic orexin neurons in mice

S Tashiro, R Yamaguchi, S Ishikawa, T Sakurai… - Scientific reports, 2016 - nature.com
Various folk remedies employ certain odorous compounds with analgesic effects. In fact,
linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate pain …

TRPA1 channels: chemical and temperature sensitivity

WJ Laursen, SN Bagriantsev, EO Gracheva - Current topics in membranes, 2014 - Elsevier
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal excitatory ion channel found
in sensory neurons of different organisms, ranging from worms to humans. Since its …

Linalool odor‐induced analgesia is triggered by TRPA1-independent pathway in mice

H Kashiwadani, Y Higa, M Sugimura… - Behavioral and Brain …, 2021 - Springer
We had recently reported that linalool odor exposure induced significant analgesic effects in
mice and that the effects were disappeared in olfactory-deprived mice in which the olfactory …

Methylglyoxal requires AC1 and TRPA1 to produce pain and spinal neuron activation

RB Griggs, DE Laird, RR Donahue, W Fu… - Frontiers in …, 2017 - frontiersin.org
Methylglyoxal (MG) is a metabolite of glucose that may contribute to peripheral neuropathy
and pain in diabetic patients. MG increases intracellular calcium in sensory neurons and …

TRPA1 channel in the airway underlies protection against airborne threats by modulating respiration and behaviour

T Kuwaki, N Takahashi - The Journal of Physiology, 2024 - Wiley Online Library
Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of cation
channels, is broadly expressed in sensory neural pathways, including the trigeminal …

Elucidating the functional evolution of heat sensors among Xenopus species adapted to different thermal niches by ancestral sequence reconstruction

S Saito, CT Saito, M Nozawa, M Tominaga - Molecular Ecology, 2019 - Wiley Online Library
Ambient temperature fluctuations are detected via the thermosensory system which allows
animals to seek preferable thermal conditions or escape from harmful temperatures …