Epigenetic pathways play a critical role in the initiation, progression, and metastasis of
cancer. Over the past few decades, significant progress has been made in the development …

Drug resistance is one of the biggest challenges in cancer treatment and limits the potential
to cure patients. In many tumors, sustained activation of the protein NRF2 makes tumor cells …

Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that
plays a key role in the human innate immune response to infection and has been …

Natural products perennially serve as prolific sources of drug leads and chemical probes,
fueling the development of numerous therapeutics. Despite their scarcity, natural products …

G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

The proteasome is a multi-catalytic protease complex that is involved in protein quality
control via three proteolytic activities (ie, caspase-, trypsin-, and chymotrypsin-like activities) …

The urgent and unmet medical demand of acute myeloid leukemia (AML) patients has
driven the drug discovery process for expansion of the landscape of AML treatment. Despite …

ABSTRACT Introduction Molecular Glue Degraders (MGDs) is a concept that refers to a
class of compounds that facilitate the interaction between two proteins or molecules within a …

Protein-protein interactions (PPIs) are fundamental to cellular signaling and transduction
which marks them as attractive therapeutic drug development targets. What were once …

Protein-protein interactions (PPIs) stabilization with molecular glues plays a crucial role in
drug discovery, albeit with significant challenges. In this study, we propose a dual-site …