Emerging roles of exosomes in Huntington's disease

H Ananbeh, P Vodicka… - International journal of …, 2021 - mdpi.com
Huntington's disease (HD) is a rare hereditary autosomal dominant neurodegenerative
disorder, which is caused by expression of mutant huntingtin protein (mHTT) with an …

[HTML][HTML] Purinergic receptors in cognitive disturbances

P Illes, H Ulrich, JF Chen, Y Tang - Neurobiology of Disease, 2023 - Elsevier
Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-
sensitive classes broadly interfere with cognitive processes both under quasi normal and …

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

AS Al‐Shami, AE Essawy… - Phytotherapy …, 2023 - Wiley Online Library
Neurodegenerative disorders are heterogeneous, debilitating, and incurable groups of brain
disorders that have common features including progressive degeneration of the structure …

[HTML][HTML] Modulation of adenosine signaling reverses 3-nitropropionic acid-induced bradykinesia and memory impairment in adult zebrafish

MT Wiprich, S Altenhofen, D Gusso… - Progress in Neuro …, 2022 - Elsevier
Huntington's disease (HD) is a neurodegenerative disorder, characterized by motor
dysfunction, psychiatric disturbance, and cognitive decline. In the early stage of HD, occurs a …

Locomotor Behavior and Memory Dysfunction Induced by 3-Nitropropionic Acid in Adult Zebrafish: Modulation of Dopaminergic Signaling

MT Wiprich, R da Rosa Vasques, D Gusso… - Molecular …, 2024 - Springer
Huntington's disease (HD) is a progressive neurodegenerative disease characterized by
neuropsychiatric disturbance, cognitive impairment, and locomotor dysfunction. In the early …

Purinergic signaling in the pathophysiology and treatment of Huntington's disease

MT Wiprich, CD Bonan - Frontiers in Neuroscience, 2021 - frontiersin.org
Huntington's disease (HD) is a devastating, progressive, and fatal neurodegenerative
disorder inherited in an autosomal dominant manner. This condition is characterized by …

Unveiling the neuroprotective properties of isoflavones: current evidence, molecular mechanisms and future perspectives

G Gong, K Ganesan, Y Wan, Y Liu… - Critical Reviews in …, 2024 - Taylor & Francis
Neurodegenerative diseases encompass a wide range of debilitating and incurable brain
disorders characterized by the progressive deterioration of the nervous system's structure …

Clinical and genetic characteristics of late‐onset Huntington's disease in a large European cohort

M Petracca, S Di Tella, M Solito, P Zinzi… - European journal of …, 2022 - Wiley Online Library
Background and purpose Huntington's disease (HD) is an autosomal dominant condition
caused by CAG‐triplet repeat expansions. CAG‐triplet repeat expansion is inversely …

Analysis of HTT CAG repeat expansion in Italian patients with amyotrophic lateral sclerosis

A Manini, D Gagliardi, M Meneri… - Annals of Clinical …, 2022 - Wiley Online Library
HTT full‐penetrance pathogenic repeat expansions, the genetic cause of Huntington's
disease (HD), have been recently reported in a minority of frontotemporal …

[HTML][HTML] Exosome Cargo in Neurodegenerative Diseases: Leveraging Their Intercellular Communication Capabilities for Biomarker Discovery and Therapeutic …

S Zhang, Y Yang, X Lv, X Zhou, W Zhao, L Meng, S Zhu… - Brain Sciences, 2024 - mdpi.com
The inexorable progression of neurodegenerative diseases (NDs), including Alzheimer's
disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and …