Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Abstract Phospholipases D (PLD) and C (PLC) hydrolyze the phosphodiesteric linkages of
the head group of membrane phospholipids. PLDs and PLCs in plants occur in different …

Sperm cryopreservation is a powerful tool for the livestock breeding program. Several
technical attempts have been made to enhance the efficiency of spermatozoa …

BACKGROUND Total fertilization failure (TFF) is the failure of all metaphase II oocytes to
fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1 …

Since the establishment of in vitro fertilization, it became evident that almost half of the
couples failed to achieve fertilization and this phenomenon was attributed to a male gamete …

Sperm-specific phospholipase C zeta (PLCζ) is widely considered to be the physiological
stimulus responsible for generating calcium (Ca2+) oscillations that induce egg activation …

Abstract STUDY QUESTION Are phospholipase C zeta 1 (PLCZ1) mutations associated with
fertilization failure (FF) after ICSI? SUMMARY ANSWER New mutations in the PLCZ1 …

Mammalian spermatozoa deliver various classes of RNAs to the oocyte during fertilization,
and many of them may regulate fertility. The objective of the present study was to determine …

Calcium (Ca2+) signals initiate egg activation across the animal kingdom and in at least
some plants. These signals are crucial for the success of development and, in the case of …

OBJECTIVE: To determine the effect of infertility-linked sperm phospholipase Cζ (PLCζ)
mutations on their ability to trigger oocyte Ca2+ oscillations and development, and also to …