For many decades, the design of new nucleoside analogs as potential therapeutic agents
focused on both sugar and nucleobase modifications. These nucleoside analogs rely on …

Hepatitis C virus (HCV) infection is a global health problem that impacts approximately 180
million individuals. Of those initially infected with HCV approximately 80% will progress to …

A substantial portion of metabolism involves transformation of phosphate esters, including
pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and …

Following the first report on the nucleoside phosphoramidate (ProTide) prodrug approach in
1990 by Chris McGuigan, the extensive investigation of ProTide technology has begun in …

Abstract Utilization of CuO nanoparticles (NPs) in agriculture, as fertilizers or pesticides,
requires understanding of their impact on plant metabolism. Inhibition of root elongation by …

Although 2′-deoxy-2′-α-F-2′-β-C-methyl (2′-F/Me) uridine nucleoside derivatives are a
successful class of antiviral drugs, this modification had not been studied in …

Despite the availability of highly effective direct-acting antiviral (DAA) regimens for the
treatment of hepatitis C virus (HCV) infections, sustained viral response (SVR) rates remain …

Fluorinated nucleosides are an important class of modified nucleosides that have
demonstrated therapeutic potential for treating various human diseases, especially viral …

HCV infection is a significant worldwide health problem and is a major cause of
hepatocellular carcinoma. The current standard of care, interferon and ribavirin, is only …

C-nucleosides have intrigued biologists and medicinal chemists since their discovery in
1950's. In that regard, C-nucleosides and their synthetic analogues have resulted in …