Sphingosine kinase 1 (SPHK1) regulates cell proliferation and survival by converting
sphingosine to the signaling mediator sphingosine 1-phosphate (S1P). SPHK1 is widely …

Abstract Sphingosine-1-phoshate (S1P) is a membrane sphingolipid involved in several
physiological processes, including cell proliferation, tissue growth, cell survival and …

Follicle-stimulating hormone (FSH) is closely related to the pathogenesis and progression of
epithelial ovarian cancer (EOC). However, until now, knowledge relating to FSH-driven …

The mitochondrial unfolded protein response (UPRmt) is an evolutionarily conserved
adaptive response that functions to maintain mitochondrial homeostasis following …

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) control antral follicular
growth by regulating several processes, such as the synthesis of hormones and signaling …

Bromopyruvate (3-BP), brominated derivative of pyruvate, possesses strong antitumor
potential, owing to its ability to inhibit multiple target molecules crucial for survival of …

Female reproduction depends on the metabolic status, especially during the period of
folliculogenesis. Even though it is believed that melatonin can improve oocyte competence …

Abstract Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid generated through
sphingosine kinase1 (SPK1)-mediated phosphorylation of sphingosine. We show here that …

Premature ovarian insufficiency (POI) means menopause before 40 years of age affecting
about 1% of women. Approaches based on cell therapy and the paracrine effects of stem …

Background and aims Sphingosine-1 phosphate (S1P) is a lysosphingolipid present in the
ovarian follicular fluid. The role of the lysosphingolipid in gonads of the female is widely …