Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

The tumor microenvironment (TME) is a major contributor to cancer malignancy including
development of therapeutic resistance, a process mediated in part through intercellular …

The role of exercise in cancer prevention and control is increasingly recognized, and based
on preclinical studies, it is hypothesized that mobilization of leukocytes plays an important …

Single-cell technologies have recently allowed the identification of multiple lymphatic
endothelial cell (LEC) subsets in subcapsular, paracortical, medullary, and other lymph …

In recent decades there has been a large focus on understanding the mechanisms of
peripheral immune cell infiltration into the central nervous system (CNS) in …

Purpose: Macrophages are critical in driving an immunosuppressive tumor
microenvironment that counteracts the efficacy of T-cell–targeting therapies. Thus, agents …

Myeloid checkpoints are receptors on the myeloid cell surface which can mediate inhibitory
signals to modulate anti-tumor immune activities. They can either inhibit cellular …

Afferent lymphatic vessels (LVs) mediate the transport of antigen and leukocytes to draining
lymph nodes (dLNs), thereby serving as immunologic communication highways between …

Brucellosis is a chronic infectious disease that is zoonotic in nature. Brucella can infect
humans through interactions with livestock, primarily via the digestive tract, respiratory tract …

Macrophage Clever-1 contributes to impaired antigen presentation and suppression of anti-
tumor immunity. This first-in-human trial investigates the safety and tolerability of Clever-1 …