Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and
subchondral bone remodeling, is a common joint degenerative disease worldwide. OA …

The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

Osteoarthritis, a chronic degenerative cartilage disease, is the leading cause of movement
disorders among humans. Although the specific pathogenesis and associated mechanisms …

Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …

Osteoarthritis (OA) is a chronic, debilitating joint disease characterized by progressive
destruction of articular cartilage. For a long time, OA has been considered as a degenerative …

Objective. Glucocorticoid‐induced osteonecrosis of the femoral head is one of the most
common causes of nontraumatic osteonecrosis of the femoral head, but its exact …

Target identification is essential for developing novel therapeutic strategies in diseases.
Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein-2, is a …

Objectives Prior studies noted that chondrocyte SIRT6 activity is repressed in older
chondrocytes rendering cells susceptible to catabolic signalling events implicated in …

Introduction Osteoarthritis is a heterogeneous joint disorder that lacks a clinically meaningful
disease modifying drug. Animal models have been beneficial in understanding basic joint …

Osteoarthritis (OA) is mainly characterized by the progressive destruction of articular
cartilage. Mounting studies have revealed that disruption of extracellular matrix (ECM) …