Visceral pain is a complex and heterogeneous pain condition that is often associated with
pain-related negative emotional states, including anxiety and depression, and can exert …

Abdominal pain, including visceral pain, is prevalent in functional gastrointestinal (GI)
disorders (FGIDs), affecting the overall quality of a patient's life. Neural circuits in the brain …

Persistent pain is a prevalent medical concern correlating with a hyperexcitable anterior
cingulate cortex (ACC). Its activity is modulated by inputs from several brain regions, but the …

Recent evidence indicates that neuronal activity within the claustrum (CLA) may be central
to cellular and behavioral responses to psychedelic hallucinogens. The CLA prominently …

Visceral and somatic pain serve as protective mechanisms against external threats.
Accumulated evidence has confirmed that the paraventricular hypothalamus (PVH) plays an …

Chronic visceral pain is a common symptom of irritable bowel syndrome (IBS). Exosomes
are involved in the development of pain. Rab27a can mediate the release of exosomes. The …

The anterior cingulate cortex (ACC) is critical for the perception and unpleasantness of pain.
1, 2, 3, 4, 5, 6 It receives nociceptive information from regions such as the thalamus and …

Aims Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, but its
pathogenesis remains incompletely understood, particularly the involvements of central …

Aberrant cognitive network activity and cognitive deficits are established features of chronic
pain. However, the nature of cognitive network alterations associated with chronic pain and …

Gastric pain has limited treatment options and the mechanisms within the central circuitry
remain largely unclear. This study investigates the central circuitry in gastric pain induced by …