Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …

The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …

Admixed populations present unique opportunities to discover the genetic factors underlying
many multifactorial diseases. The geographical position and complex history of South Africa …

Certain individuals are able to resist Mycobacterium tuberculosis infection despite persistent
and intense exposure. These persons do not exhibit adaptive immune priming as measured …

The historical impression that tuberculosis was an inherited disorder has come full circle and
substantial evidence now exists of the human genetic contribution to susceptibility to …

Infectious pathogens have long been recognized as potentially powerful agents impacting
on the evolution of human genetic diversity. Analysis of large-scale case–control studies …

Although host genetics influences susceptibility to tuberculosis (TB), few genes determining
disease outcome have been identified. We hypothesized that macrophages from individuals …

Tuberculosis (TB) is one of the most devastating chronic infectious diseases, but the role of
host genetics in disease development after infection in this disease remains unidentified …

Technological developments allow increasing numbers of markers to be deployed in case-
control studies searching for genetic factors that influence disease susceptibility. However …