Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement
on SRC function. However, a significant body of work has defined Src family kinases as key …

Advanced and recurrent gynecological cancers are associated with poor prognosis and lack
of effective treatment. The developments of the molecular mechanisms on cancer …

The drivers of recurrence and resistance in ovarian high grade serous carcinoma remain
unclear. We investigate the acquisition of resistance by collecting tumour biopsies from a …

Background Carboplatin and paclitaxel administered every 3 weeks is standard-of-care first-
line chemotherapy for epithelial ovarian cancer. The Japanese JGOG3016 trial showed a …

Since its outbreak in the last December, coronavirus disease 2019 (COVID-19) caused by
SARS-CoV-2 has rapidly spread worldwide at a pandemic proportion and thus is regarded …

Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3
(STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently …

The secretome of cancer and stromal cells generates a microenvironment that contributes to
tumour cell invasion and angiogenesis. Here we compare the secretome of human …

Importance Patients with platinum-resistant or refractory ovarian high-grade serous
carcinoma (PR-HGSC) have a poor prognosis and few therapeutic options. Preclinical …

Currently, no effective therapies exist for fibrodysplasia ossificans progressiva (FOP), a rare
congenital syndrome in which heterotopic bone is formed in soft tissues owing to …