PTEN dual lipid-and protein-phosphatase function in tumor progression
Simple Summary Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a
multifunctional tumor suppressor with protein-and lipid-phosphatase activities. The …
multifunctional tumor suppressor with protein-and lipid-phosphatase activities. The …
Nuclear PTEN's functions in suppressing tumorigenesis: Implications for rare cancers
CG Langdon - Biomolecules, 2023 - mdpi.com
Phosphatase and tensin homolog (PTEN) encodes a tumor-suppressive phosphatase with
both lipid and protein phosphatase activity. The tumor-suppressive functions of PTEN are …
both lipid and protein phosphatase activity. The tumor-suppressive functions of PTEN are …
High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog) …
KA Strand, S Lu, MF Mutryn, L Li, Q Zhou… - … and Vascular Biology, 2020 - Am Heart Assoc
Objective: Our recent work demonstrates that PTEN (phosphatase and tensin homolog) is an
important regulator of smooth muscle cell (SMC) phenotype. SMC-specific PTEN deletion …
important regulator of smooth muscle cell (SMC) phenotype. SMC-specific PTEN deletion …
PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
Y Yu, M Dai, L Huang, W Chen, E Yu, A Mendoza… - Iscience, 2023 - cell.com
PTEN encodes a tumor suppressor with lipid and protein phosphatase activities whose
dysfunction has been implicated in melanomagenesis; less is known about how its …
dysfunction has been implicated in melanomagenesis; less is known about how its …
[HTML][HTML] Recent advances in PTEN signalling axes in cancer
In over two decades since the discovery of phosphatase and tensin homologue deleted on
chromosome 10 (PTEN), nearly 18,000 publications have attempted to elucidate its …
chromosome 10 (PTEN), nearly 18,000 publications have attempted to elucidate its …
PTEN-negative endometrial cancer cells protect their genome through enhanced DDB2 expression associated with augmented nucleotide excision repair
F Hameed JS, A Devarajan, DP MS, A Bhattacharyya… - BMC cancer, 2023 - Springer
Background Endometrial cancer (EC) arises from uterine endometrium tissue and is the
most prevalent cancer of the female reproductive tract in developed countries. It has been …
most prevalent cancer of the female reproductive tract in developed countries. It has been …
Metabolic stress regulates genome-wide transcription in a PTEN-dependent manner
A Abbas, R Padmanabhan, C Eng - Human Molecular Genetics, 2020 - academic.oup.com
PTEN is implicated in a wide variety of pathophysiological conditions and traditionally
studied in the context of the PIK3–AKT–mTOR axis. Recent studies from our group and …
studied in the context of the PIK3–AKT–mTOR axis. Recent studies from our group and …
[HTML][HTML] High throughput screen identifies the DNMT1 inhibitor, 5-azacytidine, as a potent inducer of PTEN: central role for PTEN in 5-azacytidine protection against …
KA Strand, S Lu, MF Mutryn, L Li, Q Zhou… - … , and vascular biology, 2020 - ncbi.nlm.nih.gov
Objective–Our recent work demonstrates that PTEN is an important regulator of SMC
phenotype. SMC-specific PTEN deletion promotes spontaneous vascular remodeling and …
phenotype. SMC-specific PTEN deletion promotes spontaneous vascular remodeling and …
[图书][B] Microglia Pathology: An Inherent Feature of Constitutional PTEN Dysfunction
NB Sarn - 2021 - search.proquest.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting approximately 1
in 58 children by age 8 in the United States and defined by deficits in social communication …
in 58 children by age 8 in the United States and defined by deficits in social communication …
Gene expression profiling of chromosome 10 in PTEN-knockout (−/−) human neural and mesenchymal stem cells: A system biology study
The present study investigates the effects of PTEN deletion in human neuro and
mesenchymal stem cells related to the chromosome 10 gene expression profile. The RNA …
mesenchymal stem cells related to the chromosome 10 gene expression profile. The RNA …