Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the
world's population. NAFLD includes a spectrum of progressive liver disease from steatosis to …

Cardiovascular diseases remain the leading cause of death worldwide in the last decade,
accompanied by immense health and economic burdens. Heart failure (HF), as the terminal …

Abstract FUN14 domain-containing protein 1 (Fundc1)-dependent mitophagy, mainly
activated by ischemic/hypoxic preconditioning, benefits acute myocardial reperfusion injury …

Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury,
coronary circulation is a so far neglected target of cardioprotection. In this study, we …

Objective Mitochondrial dysfunction plays a dominant role in the pathogenesis of alcoholic
liver disease (ALD); however, the underlying mechanisms remain to be fully understood. We …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Mitochondria are key organelles involved in energy production as well as numerous
metabolic processes. There is a growing interest in the role of mitochondrial dysfunction in …

Aims Mitochondrial perturbations are the major culprit of the inflammatory response during
the initial phase of cerebral ischemia. The present study explored the neuroprotective effect …

Current research on human aging has largely been guided by the milestone paper
“hallmarks of aging,” which were first proposed in the seminal 2013 paper by Lopez‐Otin et …

Myocardial infarction is characterized by sudden ischemia and cardiomyocyte death.
Mitochondria have critical roles in regulating cardiomyocyte viability and can sustain …