Triple-negative (TNBC) is the most lethal subtype of breast cancer owing to high
heterogeneity, aggressive nature, and lack of treatment options. Chemotherapy remains the …

The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, but
an effective targeted therapy has not been well-established so far. Considering the lack of …

Targeting of estrogen receptor is commonly used as a first-line treatment for hormone-
positive breast cancer patients, and is considered as a keystone of systemic cancer therapy …

Breast cancer (BC) is the second most common cause of cancer deaths. Triple‐negative
breast cancer (TNBC) does not show immunohistochemical expression of oestrogen …

Abstract Triple Negative Breast Cancer (TNBC) is a highly heterogeneous subtype of breast
cancer that lacks the expression of oestrogen receptors, progesterone receptors and human …

Triple negative breast cancer (TNBC) is one of the most aggressive subtypes of breast
cancer accounting for 15-20% of cases and is defined by the lack of hormonal receptors viz …

Background Triple-negative breast cancers represent an important clinical challenge, as
these cancers do not respond to conventional endocrine therapies or other available …

The major obstacle in successfully treating triple-negative breast cancer (TNBC) is
resistance to cytotoxic chemotherapy, the mainstay of treatment in this disease. Previous …