Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Recent discoveries are redefining our view of cellular senescence as a trigger of tissue
remodelling that acts during normal embryonic development and upon tissue damage. To …

Background: Senescent cells (SCs) are involved in proliferative disorders, but their role in
pulmonary hypertension remains undefined. We investigated SCs in patients with …

Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal
activation during embryonic development or normal adult life is linked with beneficial …

Background: Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II, a potent
vasoconstrictor, to angiotensin-(1–7) and is also a membrane protein that enables …

Pulmonary arterial hypertension (PAH) remains a mysterious killer that, like cancer, is
characterized by tremendous complexity. PAH development occurs under sustained and …

Mitochondrial dysfunction, inflammation, and mutant bone morphogenetic protein receptor 2
(BMPR2) are associated with pulmonary arterial hypertension (PAH), an incurable disease …

Cellular senescence, the irreversible loss of replicative capacity in somatic cells, plays a
causal role in the development of age-related pathology and in a number of age-related …

Although the causal pathomechanisms contributing to remodelling of the pulmonary
vascular bed in pulmonary arterial hypertension (PAH) are still unclear, several analogous …

Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and
diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial …