The advances in brucellosis vaccines

H Hou, X Liu, Q Peng - Vaccine, 2019 - Elsevier
Brucellosis is a worldwide zoonosis affecting animal and human health. Till now, there is no
effective vaccine licensed for brucellosis in humans. Although M5, H38 and 45/20 vaccines …

Emerging vaccine informatics

Y He, R Rappuoli, AS De Groot… - BioMed Research …, 2010 - Wiley Online Library
Vaccine informatics is an emerging research area that focuses on development and
applications of bioinformatics methods that can be used to facilitate every aspect of the …

Vaxign: the first web‐based vaccine design program for reverse vaccinology and applications for vaccine development

Y He, Z Xiang, HLT Mobley - BioMed Research International, 2010 - Wiley Online Library
Vaxign is the first web‐based vaccine design system that predicts vaccine targets based on
genome sequences using the strategy of reverse vaccinology. Predicted features in the …

Modeling biomedical experimental processes with OBI

RR Brinkman, M Courtot, D Derom, JM Fostel… - Journal of biomedical …, 2010 - Springer
Background Experimental descriptions are typically stored as free text without using
standardized terminology, creating challenges in comparison, reproduction and analysis …

PanRV: Pangenome-reverse vaccinology approach for identifications of potential vaccine candidates in microbial pangenome

K Naz, A Naz, ST Ashraf, M Rizwan, J Ahmad… - BMC …, 2019 - Springer
Background A revolutionary diversion from classical vaccinology to reverse vaccinology
approach has been observed in the last decade. The ever-increasing genomic and …

An open source knowledge graph ecosystem for the life sciences

TJ Callahan, IJ Tripodi, AL Stefanski, L Cappelletti… - Scientific Data, 2024 - nature.com
Translational research requires data at multiple scales of biological organization.
Advancements in sequencing and multi-omics technologies have increased the availability …

Analyses of Brucella Pathogenesis, Host Immunity, and Vaccine Targets using Systems Biology and Bioinformatics

Y He - Frontiers in cellular and infection microbiology, 2012 - frontiersin.org
Brucella is a Gram-negative, facultative intracellular bacterium that causes zoonotic
brucellosis in humans and various animals. Out of 10 classified Brucella species, B …

Immunoinformatics: an integrated scenario

N Tomar, RK De - Immunology, 2010 - Wiley Online Library
Genome sequencing of humans and other organisms has led to the accumulation of huge
amounts of data, which include immunologically relevant data. A large volume of clinical …

Ontologizing health systems data at scale: making translational discovery a reality

TJ Callahan, AL Stefanski, JM Wyrwa, C Zeng… - NPJ Digital …, 2023 - nature.com
Common data models solve many challenges of standardizing electronic health record
(EHR) data but are unable to semantically integrate all of the resources needed for deep …

Vaccines meet big data: State-of-the-Art and future prospects. From the classical 3Is (“Isolate–Inactivate–Inject”) vaccinology 1.0 to vaccinology 3.0, vaccinomics, and …

NL Bragazzi, V Gianfredi, M Villarini… - Frontiers in public …, 2018 - frontiersin.org
Vaccines are public health interventions aimed at preventing infections-related mortality,
morbidity, and disability. While vaccines have been successfully designed for those …