Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …

The relatively rapid shift from consuming preagricultural wild foods for thousands of years, to
consuming postindustrial semi-processed and ultra-processed foods endemic of the …

Background Alzheimer's disease is the most common neurodegenerative disease
worldwide. Metabolic syndrome is the most common metabolic and endocrine disease in the …

Diet is a critical element determining human health and diseases, and unbalanced food
habits are major risk factors for the development of obesity and related metabolic disorders …

Obesity, prediabetes, and diabetes are growing in prevalence worldwide. These metabolic
disorders are associated with neurodegenerative diseases, particularly Alzheimer's disease …

Designing strategies to utilize the synergistic effect of probiotics and prebiotics is a
promising way in treating metabolic-related diseases. Here, inspired by the mutually …

Diabetes increases the likelihood of developing depression and vice versa. Research on
this bidirectional association has somewhat managed to delineate the interplay among …

Although the detrimental effects of diabetes mellitus/hyperglycemia have been observed in
many liver disease models, the function and mechanism of hyperglycemia regulating liver …

Background APOE 4 is the strongest genetic risk factor for Alzheimer's disease (AD), and
obesity is a strong environmental risk factor for AD. These factors result in multiple central …