The role of TOR in autophagy regulation from yeast to plants and mammals
The target of rapamycin (TOR) is a conserved Ser/Thr kinase that controls cell growth by
activating an array of anabolic processes including protein synthesis, transcription, and …
activating an array of anabolic processes including protein synthesis, transcription, and …
TOR complex 2: a signaling pathway of its own
N Cybulski, MN Hall - Trends in biochemical sciences, 2009 - cell.com
Research on TOR has grown exponentially during the last decade, generating a complex
model of the TOR signaling network. Rapamycin treatment provides a simple and …
model of the TOR signaling network. Rapamycin treatment provides a simple and …
Systemic analysis of inducible target of rapamycin mutants reveal a general metabolic switch controlling growth in Arabidopsis thaliana
C Caldana, Y Li, A Leisse, Y Zhang… - The Plant …, 2013 - Wiley Online Library
The target of rapamycin (TOR) pathway is a major regulator of growth in all eukaryotes,
integrating energy, nutrient and stress signals into molecular decisions. By using large …
integrating energy, nutrient and stress signals into molecular decisions. By using large …
Exaptive evolution of target of rapamycin signaling in multicellular eukaryotes
JO Brunkard - Developmental Cell, 2020 - cell.com
Target of rapamycin (TOR) is a protein kinase that coordinates metabolism with nutrient and
energy availability in eukaryotes. TOR and its primary interactors, RAPTOR and LST8, have …
energy availability in eukaryotes. TOR and its primary interactors, RAPTOR and LST8, have …
TOR regulation of AGC kinases in yeast and mammals
E Jacinto, A Lorberg - Biochemical Journal, 2008 - portlandpress.com
The TOR (target of rapamycin), an atypical protein kinase, is evolutionarily conserved from
yeast to man. Pharmacological studies using rapamycin to inhibit TOR and yeast genetic …
yeast to man. Pharmacological studies using rapamycin to inhibit TOR and yeast genetic …
Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common …
Nutrients are essential for cell growth and division. Screening of Schizosaccharomyces
pombe temperature‐sensitive strains led to the isolation of a nutrient‐insensitive mutant, tor2 …
pombe temperature‐sensitive strains led to the isolation of a nutrient‐insensitive mutant, tor2 …
TORC 1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
Target of rapamycin complex 1 (TORC 1) is implicated in growth control and aging from
yeast to humans. Fission yeast is emerging as a popular model organism to study TOR …
yeast to humans. Fission yeast is emerging as a popular model organism to study TOR …
The Protein Kinase Tor1 Regulates Adhesin Gene Expression in Candida albicans
RJ Bastidas, J Heitman, ME Cardenas - PLoS pathogens, 2009 - journals.plos.org
Eukaryotic cell growth is coordinated in response to nutrient availability, growth factors, and
environmental stimuli, enabling cell–cell interactions that promote survival. The rapamycin …
environmental stimuli, enabling cell–cell interactions that promote survival. The rapamycin …
Transcriptome analysis reveals new insight into appressorium formation and function in the rice blast fungus Magnaporthe oryzae
Background Rice blast disease is caused by the filamentous Ascomycetous fungus
Magnaporthe oryzae and results in significant annual rice yield losses worldwide. Infection …
Magnaporthe oryzae and results in significant annual rice yield losses worldwide. Infection …
TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases
J Petersen, P Nurse - Nature cell biology, 2007 - nature.com
The coupling of growth to cell cycle progression allows eukaryotic cells to divide at particular
sizes depending on nutrient availability. In fission yeast, this coupling involves the Spc1/Sty1 …
sizes depending on nutrient availability. In fission yeast, this coupling involves the Spc1/Sty1 …