ABSTRACT The Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss‐of‐
function and gain‐of‐function studies, as well as lineage tracing, through gene …

Abstract Purpose of Review The purpose of the review is to summarize the expression and
function of CSF1R and its ligands in bone homeostasis and constraints on therapeutic …

Although osteoblasts and osteocytes are descended from the same lineage, they each have
unique and essential roles in bone. Targeting gene deletion to osteoblasts and osteocytes …

Gene knockout is a technique routinely used in basic experimental research, particularly in
mouse skeletal and developmental studies. Tamoxifen-induced Cre/loxp system is known …

Abstract Purpose of Review To summarise the evidence regarding the effects of gender-
affirming hormone therapy (GAHT) on bone health in transgender people, to identify key …

Background & Aims Restricted gastric motor functions contribute to aging-associated
undernutrition, sarcopenia, and frailty. We previously identified a decline in interstitial cells of …

Estrogen receptor α is commonly used in synthetic biology to control the activity of genome
editing tools. The activating ligands, estrogens, however, interfere with various cellular …

Bone formation and resorption are typically coupled, such that the efficacy of anabolic
osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL …

Estrogen is known to regulate bone metabolism in both women and men, but substantial
gaps remain in our knowledge of estrogen and estrogen receptor alpha (ERα) regulation of …

Pain is the prime symptom of osteoarthritis (OA) that directly affects the quality of life. Protein
kinase Cδ (PKCδ/Prkcd) plays a critical role in OA pathogenesis; however, its significance in …