This study was aimed to explore the effects of fucoidan on iron overload and ferroptosis-
induced liver injury, and the underlying mechanisms in rats exposed to alcohol. Sprague …

Iron homeostasis is regulated by hepcidin, a hepatic hormone that controls dietary iron
absorption and plasma iron concentration. Hepcidin binds to the only known iron export …

BACKGROUND: The checkpoint kinase 1 (CHEK1) and glutamine-fructose-6-phosphate
aminotransferase 1 (GFPT1) genes have been reported to have a crucial role in …

Objective: To delve into the primary active ingredients and mechanism of Pueraria lobata for
alleviating iron overload in alcoholic liver disease. Methods: Pueraria lobata's potential …

Iron loading is regarded as the primary cause of endocrine abnormalities in thalassemia
major patients. Thus, the purpose of the current research was to explore the impact of …

Background Thalassemia is a hemoglobin synthesis disorder that causes patients to need
lifelong blood transfusions, leading to iron overload and alter organ function, including the …

In spite of recent advances in iron overload, elevate iron deposition in pituitary gonadotropic
cells keep on one of the main complications in thalassemic patients. Hypogonadism, mainly …