Lactose is one of the most widespread excipients used in the pharmaceutical industry.
Because of its water solubility and acceptable flowability, lactose is generally added into …

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug
manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and …

The purpose of this study was to investigate the influence of various powder agglomeration
processes on tableting mixture flow and compaction properties. Four different granulation …

In this paper, two types of parameters representing tabletability and compactibility profiles of
a series of α-lactose monohydrate powders, ranging in particle size from approximately 3.5 …

This study investigated deformation mechanisms of some commonly used pharmaceutical
fillers, such as microcrystalline cellulose, lactose, dicalcium phosphate, isomalt and …

This chapter describes the application of lactose as excipient in the pharmaceutical industry.
About 60%–70% of pharmaceutical dosage forms contain lactose, and in volume it is one of …

The aim of this study was to prepare spherical agglomerates of lactose and to evaluate their
physicochemical properties, flow properties, particle friability and compaction properties …

Mini-tablets are solid dosage forms with increasing interest for pharmaceutical industry due
to clinical and biopharmaceutical benefits. But technological aspects on mini-tableting are …

Before designing tablet formulations, it is important to understand the “Tableting Properties”
of excipients and API (active pharmaceutical ingredient) powders. Those properties refer to …

This study investigates the effect of particle size on the compression characteristics of wet-
(fluid-bed granulation–FBG) and dry-granulated (slugging–DGS) tableting mixtures. Particle …