Functional probes for the diagnosis and treatment of infectious diseases

Z Fan, Y Liu, Y Ye, Y Liao - Aggregate, 2024 - Wiley Online Library
Infectious diseases present significant challenges to global health, thereby extensively
affecting both human society and the economy. In recent years, functional probes have …

Stimuli‐responsive linkers and their application in molecular imaging

J Wang, M Liu, X Zhang, X Wang, M Xiong, D Luo - Exploration, 2024 - Wiley Online Library
Molecular imaging is a non‐invasive imaging method that is widely used for visualization
and detection of biological events at cellular or molecular levels. Stimuli‐responsive linkers …

Spirostrain-accelerated chemiexcitation of dioxetanes yields unprecedented detection sensitivity in chemiluminescence bioassays

R Tannous, O Shelef, S Gutkin, M David… - ACS Central …, 2023 - ACS Publications
Chemiluminescence is a fascinating phenomenon that involves the generation of light
through chemical reactions. The light emission from adamantyl-phenoxy-1, 2-dioxetanes …

Enzymatic Activity Profiling Using an Ultrasensitive Array of Chemiluminescent Probes for Bacterial Classification and Characterization

O Shelef, T Kopp, R Tannous, M Arutkin… - Journal of the …, 2024 - ACS Publications
Identification and characterization of bacterial species in clinical and industrial settings
necessitate the use of diverse, labor-intensive, and time-consuming protocols as well as the …

Chemiluminescent duplex analysis using phenoxy-1, 2-dioxetane luminophores with color modulation

S Gutkin, R Tannous, Q Jaber, M Fridman… - Chemical Science, 2023 - pubs.rsc.org
Multiplex technology is an important emerging field, in diagnostic sciences, that enables the
simultaneous detection of several analytes in a single sample. The light-emission spectrum …

Chemiexcitation Acceleration of 1, 2‐Dioxetanes by Spiro‐Fused Six‐Member Rings with Electron‐Withdrawing Motifs

M David, T Leirikh, O Shelef, S Gutkin… - Angewandte Chemie …, 2024 - Wiley Online Library
The chemiluminescent light‐emission pathway of phenoxy‐1, 2‐dioxetane luminophores
attracts growing interest within the scientific community. Dioxetane probes undergoing rapid …

Neuraminidase-activatable NIR fluorescent probe for influenza virus ratiometric imaging in living cells and colorimetric detection on cotton swabs

GQ Zhang, H Chang, Z Gao, Y Deng, S Zeng… - ACS Materials …, 2023 - ACS Publications
Influenza, as one of the most serious communicable respiratory infectious diseases, is
caused by influenza viruses. Neuraminidase (NA), also referred to as sialidase, is an …

Hyper-Responsive Chemiluminescent Probe Reveals Distinct PYRase Activity in Pseudomonas aeruginosa

R Tannous, O Shelef, T Kopp, M Fridman… - Bioconjugate …, 2024 - ACS Publications
Pyrrolidone carboxyl peptidase, commonly known as PYRase, is an exopeptidase that
catalytically cleaves an N-terminal pyroglutamic acid from peptides or proteins. The diverse …

Boosting Chemiexcitation of Phenoxy-1, 2-dioxetanes through 7-Norbornyl and Homocubanyl Spirofusion

S Gutkin, O Shelef, Z Babjaková, LA Tomanová… - JACS Au, 2024 - ACS Publications
The chemiluminescent light-emission pathway of phenoxy-1, 2-dioxetane luminophores is
increasingly attracting the scientific community's attention. Dioxetane probes that undergo …

Dual Chemiexcitation by a Unique Dioxetane Scaffold Gated by an OR Logic Set of Triggers

M David, Q Jaber, M Fridman… - Chemistry–A European …, 2023 - Wiley Online Library
Abstract Chemiexcitation of phenoxy‐1, 2‐dioxetane chemiluminescent luminophores is
initiated by electron transfer from a meta‐positioned phenolate ion to the peroxide …