The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is
probably influenced by both genetic and environmental risk factors. A strong genetic risk …

Neuronal migration is, along with axon guidance, one of the fundamental mechanisms
underlying the wiring of the brain. As other organs, the nervous system has acquired the …

The correct positioning of neurons during development—achieved through directed
migration—is the basis for proper brain function. Several decades of research have yielded …

Advances in the study of brain development over the last decades, especially recent findings
regarding the evolutionary expansion of the human neocortex, and large-scale analyses of …

Lamination of neurons and fibre projections is a fundamental organizational principle of the
mammalian cerebral cortex. A laminated organization is likely to be essential for cortical …

Cajal-Retzius (CR) cells are an enigmatic class of neurons located at the surface of the
cerebral cortex, playing a major role in cortical development. In this review, we discuss …

Recent evidence suggests that schizophrenia may result from alterations of integration of
signaling mediated by multiple neurotransmitter systems. Abnormalities of associated …

Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …

The evolutionarily ancient low-density lipoprotein (LDL) receptor gene family represents a
class of widely expressed cell surface receptors. Since the dawn of the first primitive …

In addition to the fundamental role of the extracellular glycoprotein Reelin in neuronal
development and adult synaptic plasticity, alterations in Reelin-mediated signaling have …