Apoptosis is a major form of cell death, characterized initially by a series of stereotypic
morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

We report here the purification of the third protein factor, Apaf-3, that participates in caspase-
3 activation in vitro. Apaf-3 was identified as a member of the caspase family, caspase-9 …

Caspases are intracellular proteases that function as initiators and effectors of apoptosis.
The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro–caspase-9 …

We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from
HeLa cell cytosol that participates in the cytochrome c–dependent activation of caspase-3 …

Zinc is one of the most abundant nutritionally essential elements in the human body. It is
found in all body tissues with 85% of the whole body zinc in muscle and bone, 11% in the …

▪ Abstract Apoptosis, or programmed cell death, is involved in development, elimination of
damaged cells, and maintenance of cell homeostasis. Deregulation of apoptosis may cause …

There is compelling evidence that members of the caspase (interleukin-1β converting
enzyme/CED-3) family of cysteine proteases and the cytotoxic lymphocyte-derived serine …

Caspases (cysteinyl aspartate-specific proteinases) mediate highly specific proteolytic
cleavage events in dying cells, which collectively manifest the apoptotic phenotype. The key …

Significance: The intrinsic apoptosis pathway is conserved from worms to humans and plays
a critical role in the normal development and homeostatic control of adult tissues. As a result …