Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

Objective Schizophrenia results in cognitive impairments as well as positive, negative, and
disorganized symptomatology. The present study examines the extent to which these …

Psychotic syndromes can be understood as disorders of adaptation to social context.
Although heritability is often emphasized, onset is associated with environmental factors …

Cognitive deficits are one of the core symptoms of schizophrenia that evolve during the
course of schizophrenia, after being originated even before the onset of illness. Existing …

According to the social defeat (SD) hypothesis, published in 2005, long-term exposure to the
experience of SD may lead to sensitization of the mesolimbic dopamine (DA) system and …

Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

Although dementia praecox or schizophrenia has been considered a unique disease entity
for the past century, its definitions and boundaries have continued to vary over this period. At …

Although we have studied schizophrenia as a major disease entity over the past century, its
causes and pathogenesis remain obscure. In this article, we critically review genetic and …