The Innate Immune Response to Mycobacterium tuberculosis Infection

MM Ravesloot-Chávez, E Van Dis… - Annual review of …, 2021 - annualreviews.org
Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Innate and adaptive cellular immune responses to Mycobacterium tuberculosis infection

KD Mayer-Barber, DL Barber - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the coordinated
efforts of innate and adaptive immune cells. Diverse pulmonary myeloid cell populations …

The role of dendritic cells in Mycobacterium tuberculosis infection

A Mihret - Virulence, 2012 - Taylor & Francis
The immune response against Mycobacterium tuberculosis is multifactorial, involving a
network of innate and adaptive immune responses. Characterization of the immune …

Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines

LL Roberts, CM Robinson - Immunology, 2014 - Wiley Online Library
Tuberculosis (TB) remains a major global health problem accounting for millions of deaths
annually. Approximately one‐third of the world's population is infected with the causative …

What lies beneath the airway mucosal barrier? Throwing the spotlight on antigen‐presenting cell function in the lower respiratory tract

S Pai, V Muruganandah, A Kupz - Clinical & Translational …, 2020 - Wiley Online Library
The global prevalence of respiratory infectious and inflammatory diseases remains a major
public health concern. Prevention and management strategies have not kept pace with the …

Lipid metabolism and Type VII secretion systems dominate the genome scale virulence profile of Mycobacterium tuberculosis in human dendritic cells

TA Mendum, H Wu, AM Kierzek, GR Stewart - BMC genomics, 2015 - Springer
Background Mycobacterium tuberculosis continues to kill more people than any other
bacterium. Although its archetypal host cell is the macrophage, it also enters, and survives …

Host Cell Death and Modulation of Immune Response against Mycobacterium tuberculosis Infection

A Vu, I Glassman, G Campbell, S Yeganyan… - International Journal of …, 2024 - mdpi.com
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), a prevalent
infectious disease affecting populations worldwide. A classic trait of TB pathology is the …

Immunotherapeutic effects of recombinant adenovirus encoding interleukin 12 in experimental pulmonary tuberculosis

DA Mata‐Espinosa, A Francisco‐Cruz… - Scandinavian …, 2019 - Wiley Online Library
High dose of Mycobacterium tuberculosis (Mtb) strain H37Rv administered by intratracheal
injection in BALB/c mice induce progressive tuberculosis (TB). In this model, during the first …

ESAT-6 targeting to DEC205+ antigen presenting cells induces specific-T cell responses against ESAT-6 and reduces pulmonary infection with virulent …

A Silva-Sánchez, S Meza-Pérez, A Flores-Langarica… - PLoS …, 2015 - journals.plos.org
Airways infection with Mycobacterium tuberculosis (Mtb) is contained mostly by T cell
responses, however, Mtb has developed evasion mechanisms which affect antigen …

Differential activation of dendritic cells by Mycobacterium tuberculosis Beijing genotype

JE Reyes-Martínez, E Nieto-Patlán… - Immunological …, 2014 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) inhibits dendritric cells (DC) function in order to delay T
cell response. Furthermore, there is increasing evidence that genetic diversity of Mtb strains …