CD8+ Tregs have been long described and significant progresses have been made about
their phenotype, their functional mechanisms, and their suppressive ability compared to …

Invariant natural killer T (iNKT) cells serve as a bridge between innate and adaptive
immunity and have been shown to play an important role in immune regulation, defense …

Regulatory T cells (Tregs) are critical to regulating maternal T-cell activation against
trophoblast; however, the characteristics of maternal Tregs during pregnancy have not been …

Chronic graft-versus-host-disease (cGVHD) can cause multiorgan system disease, typically
with autoimmune-like features, resulting in high mortality and morbidity caused by treatment …

Graft-versus-host disease (GVHD) is driven by extensive activation and proliferation of
alloreactive donor T cells causing significant morbidity and mortality following allogeneic …

How to induce immune tolerance without long-term need for immunosuppressive drugs has
always been a central problem in solid organ transplantation. Modulating immunoregulatory …

The goal of the study was to elucidate the cellular and molecular mechanisms by which a
clinically applicable immune tolerance regimen of combined bone marrow and heart …

Objective: Events occurring during the initial phase of human immunodeficiency virus (HIV)
infection are intriguing because of their dramatic impact on the subsequent course of the …

Myeloid-derived suppressor cells (MDSCs) are innate immune cells that acquire the
capacity to suppress adaptive immune responses. In the context of allogeneic hematopoietic …

The goals of tolerance in patients with solid organ transplants are to eliminate the lifelong
need for immunosuppressive (IS) drugs and to prevent graft loss due to rejection or drug …