Metagenomics for pathogen detection in public health
Traditional pathogen detection methods in public health infectious disease surveillance rely
upon the identification of agents that are already known to be associated with a particular …
upon the identification of agents that are already known to be associated with a particular …
Recent advances in genomic DNA sequencing of microbial species from single cells
RS Lasken, JS McLean - Nature Reviews Genetics, 2014 - nature.com
The vast majority of microbial species remain uncultivated and, until recently, about half of
all known bacterial phyla were identified only from their 16S ribosomal RNA gene sequence …
all known bacterial phyla were identified only from their 16S ribosomal RNA gene sequence …
Assembling single-cell genomes and mini-metagenomes from chimeric MDA products
Recent advances in single-cell genomics provide an alternative to largely gene-centric
metagenomics studies, enabling whole-genome sequencing of uncultivated bacteria …
metagenomics studies, enabling whole-genome sequencing of uncultivated bacteria …
High‐throughput identification and diagnostics of pathogens and pests: overview and practical recommendations
High‐throughput identification technologies provide efficient tools for understanding the
ecology and functioning of microorganisms. Yet, these methods have been only rarely used …
ecology and functioning of microorganisms. Yet, these methods have been only rarely used …
From cultured to uncultured genome sequences: metagenomics and modeling microbial ecosystems
Microorganisms and the viruses that infect them are the most numerous biological entities
on Earth and enclose its greatest biodiversity and genetic reservoir. With strength in their …
on Earth and enclose its greatest biodiversity and genetic reservoir. With strength in their …
Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum
The “dark matter of life” describes microbes and even entire divisions of bacterial phyla that
have evaded cultivation and have yet to be sequenced. We present a genome from the …
have evaded cultivation and have yet to be sequenced. We present a genome from the …
Characterizing the genetic basis of bacterial phenotypes using genome-wide association studies: a new direction for bacteriology
Genome-wide association studies (GWASs) have become an increasingly important
approach for eukaryotic geneticists, facilitating the identification of hundreds of genetic …
approach for eukaryotic geneticists, facilitating the identification of hundreds of genetic …
Heme acquisition mechanisms of Porphyromonas gingivalis – strategies used in a polymicrobial community in a heme‐limited host environment
JW Smalley, T Olczak - Molecular Oral Microbiology, 2017 - Wiley Online Library
Porphyromonas gingivalis, a main etiologic agent and key pathogen responsible for
initiation and progression of chronic periodontitis requires heme as a source of iron and …
initiation and progression of chronic periodontitis requires heme as a source of iron and …
An in vitrobiofilm model system maintaining a highly reproducible species and metabolic diversity approaching that of the human oral microbiome
Background Our knowledge of microbial diversity in the human oral cavity has vastly
expanded during the last two decades of research. However, much of what is known about …
expanded during the last two decades of research. However, much of what is known about …
Porphyromonas gingivalis outside the oral cavity
S Bregaint, E Boyer, SB Fong, V Meuric… - Odontology, 2022 - Springer
Porphyromonas gingivalis, a Gram-negative anaerobic bacillus present in periodontal
disease, is considered one of the major pathogens in periodontitis. A literature search for …
disease, is considered one of the major pathogens in periodontitis. A literature search for …