Approved antiviral drugs over the past 50 years

E De Clercq, G Li - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …

Human cytomegalovirus latency and reactivation in allogeneic hematopoietic stem cell transplant recipients

L Stern, B Withers, S Avdic, D Gottlieb… - Frontiers in …, 2019 - frontiersin.org
Human cytomegalovirus (HCMV) reactivation is a major infectious cause of morbidity and
mortality after allogeneic hematopoietic stem cell transplantation (HSCT). HCMV is a …

Letermovir prophylaxis for cytomegalovirus in hematopoietic-cell transplantation

FM Marty, P Ljungman, RF Chemaly… - … England Journal of …, 2017 - Mass Medical Soc
Background Cytomegalovirus (CMV) infection remains a common complication after
allogeneic hematopoietic-cell transplantation. Letermovir is an antiviral drug that inhibits the …

Letermovir for the prevention of cytomegalovirus infection and disease in transplant recipients: an evidence-based review

G El Helou, RR Razonable - Infection and drug resistance, 2019 - Taylor & Francis
Cytomegalovirus (CMV) is a leading opportunistic infection in immune compromised
patients, including allogeneic hematopoietic stem cell (HSCT) or solid organ transplant …

Antiviral prophylaxis for cytomegalovirus infection in allogeneic hematopoietic cell transplantation

K Chen, MP Cheng, SP Hammond, H Einsele… - Blood …, 2018 - ashpublications.org
Patients treated with allogeneic hematopoietic cell transplantation (HCT) are at risk of
cytomegalovirus (CMV) reactivation and disease, which results in increased morbidity and …

The human cytomegalovirus terminase complex as an antiviral target: a close-up view

G Ligat, R Cazal, S Hantz, S Alain - FEMS microbiology reviews, 2018 - academic.oup.com
Human cytomegalovirus (HCMV) is responsible for life-threatening infections in
immunocompromised individuals and can cause serious congenital malformations …

Clinical development of letermovir and maribavir: Overview of human cytomegalovirus drug resistance

J Piret, G Boivin - Antiviral research, 2019 - Elsevier
The prevention and treatment of human cytomegalovirus (HCMV) infections is based on the
use of antiviral agents that currently target the viral DNA polymerase and that may cause …

[HTML][HTML] Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction

E Maidji, M Somsouk, JM Rivera, PW Hunt… - PLoS …, 2017 - journals.plos.org
Although invasive cytomegalovirus (CMV) disease is uncommon in the era of antiretroviral
therapy (ART), asymptomatic CMV coinfection is nearly ubiquitous in HIV infected …

Moving past ganciclovir and foscarnet: advances in CMV therapy

M Hakki - Current hematologic malignancy reports, 2020 - Springer
Abstract Purpose of Review CMV DNA polymerase inhibitors such as ganciclovir and
foscarnet have dramatically reduced the burden of CMV infection in the HCT recipient …

Anti-CMV therapy, what next? A systematic review

C Gourin, S Alain, S Hantz - Frontiers in Microbiology, 2023 - frontiersin.org
Human cytomegalovirus (HCMV) is one of the main causes of serious complications in
immunocompromised patients and after congenital infection. There are currently drugs …