Exploring the expanding universe of host-virus interactions mediated by viral RNA

A Castello, L Álvarez, W Kamel, L Iselin, J Hennig - Molecular Cell, 2024 - cell.com
RNA is a central molecule in RNA virus biology; however, the interactions that it establishes
with the host cell are only starting to be elucidated. In recent years, a methodology revolution …

Post-transcriptional gene regulation: From mechanisms to RNA chemistry and therapeutics

C Bonnet, AL Dian, T Espie-Caullet, L Fabbri… - Bulletin du …, 2024 - Elsevier
A better understanding of the RNA biology and chemistry is necessary to then develop new
RNA therapeutic strategies. This review is the synthesis of a series of conferences that took …

Proteomics-based determination of double-stranded RNA interactome reveals known and new factors involved in Sindbis virus infection

E Girardi, M Messmer, P Lopez, A Fender, J Chicher… - Rna, 2023 - rnajournal.cshlp.org
Viruses are obligate intracellular parasites, which depend on the host cellular machineries
to replicate their genome and complete their infectious cycle. Long double-stranded (ds) …

Viral RNA Is a Hub for Critical Host–Virus Interactions

A Castello, L Iselin - Virus Infected Cells, 2023 - Springer
RNA is a central molecule in the life cycle of viruses, acting not only as messenger (m) RNA
but also as a genome. Given these critical roles, it is not surprising that viral RNA is a hub for …

Incorporation of genome-bound cellular proteins into HIV-1 particles regulates viral infection

M Garcia-Moreno, R Truman, H Chen, L Iselin… - bioRxiv, 2023 - biorxiv.org
The initial steps of the human immunodeficiency virus 1 (HIV-1) lifecycle are regulated by
cellular RNA-binding proteins (RBPs). To understand the scope of these early host-virus …