Monounsaturated fatty acids in obesity-related inflammation

G Ravaut, A Légiot, KF Bergeron… - International journal of …, 2020 - mdpi.com
Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

Regulation of energy metabolism by long-chain fatty acids

MT Nakamura, BE Yudell, JJ Loor - Progress in lipid research, 2014 - Elsevier
In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids …

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

H Guillou, D Zadravec, PGP Martin… - Progress in lipid research, 2010 - Elsevier
In mammalian cells, elongases and desaturases play critical roles in regulating the length
and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In …

A subpopulation of lipogenic brown adipocytes drives thermogenic memory

P Lundgren, PV Sharma, L Dohnalová, K Coleman… - Nature …, 2023 - nature.com
Sustained responses to transient environmental stimuli are important for survival. The
mechanisms underlying long-term adaptations to temporary shifts in abiotic factors remain …

Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism

MT Flowers, JM Ntambi - Current opinion in lipidology, 2008 - journals.lww.com
Recent studies in humans and animal models have highlighted that modulation of stearoyl-
coenzyme A desaturase 1 activity by dietary intervention or genetic manipulation strongly …

Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis

M Miyazaki, MT Flowers, H Sampath, K Chu… - Cell metabolism, 2007 - cell.com
Summary Stearoyl-CoA desaturase-1 (SCD1), a critical regulator of energy metabolism,
catalyzes the synthesis of monounsaturated fats. To understand the tissue-specific role of …

Role of oleic acid in the gut-liver axis: from diet to the regulation of its synthesis via stearoyl-CoA desaturase 1 (SCD1)

E Piccinin, M Cariello, S De Santis, S Ducheix… - Nutrients, 2019 - mdpi.com
The consumption of an olive oil rich diet has been associated with the diminished incidence
of cardiovascular disease and cancer. Several studies have attributed these beneficial …

The role of stearoyl‐CoA desaturase in obesity, insulin resistance, and inflammation

H Sampath, JM Ntambi - Annals of the New York Academy of …, 2011 - Wiley Online Library
Stearoyl‐CoA desaturase 1 (SCD1) is an essential lipogenic enzyme that has been shown
to play an intrinsic role in the development of obesity and related conditions, such as insulin …

Stearoyl-CoA desaturase: rogue or innocent bystander?

L Hodson, BA Fielding - Progress in lipid research, 2013 - Elsevier
Different lipid fractions in humans have characteristic fatty acid profiles and these are
maintained partly through diet and to a lesser extent through endogenous synthesis. The …

Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats

H Poudyal, SK Panchal, J Waanders, L Ward… - The Journal of nutritional …, 2012 - Elsevier
Chia seeds contain the essential fatty acid, α-linolenic acid (ALA). This study has assessed
whether chia seeds attenuated the metabolic, cardiovascular and hepatic signs of a high …