Safe and effective use of drugs requires an understanding of metabolism and transport. We
identified the 100 most prescribed drugs in six countries and conducted a literature search …

The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature
for the polymorphic human CYP3A5 gene. Genetic variation within the CYP3A5 gene locus …

Precision dosing strategies require accounting for between‐patient variability in
pharmacokinetics together with subsequent pharmacodynamic differences. Liquid biopsy is …

Typically, therapeutic proteins (TPs) have a low risk for eliciting meaningful drug interactions
(DIs). However, there are select instances where TP drug interactions (TP‐DIs) of clinical …

ImmunoGen developed mirvetuximab soravtansine as an antibody–drug conjugate
comprising of a humanized anti-folate receptor—α (FRα) monoclonal antibody of IgG1 k …

Abstract Background and Objective An ever-growing body of evidence supports the impact
of cytokine modulation on the patient's phenotypic drug response. The aim of this systematic …

SARS-CoV-2-mediated interactions with drug metabolizing enzymes and membrane
transporters (DMETs) in different tissues, especially lung, the main affected organ may limit …

During systemic inflammation, pro‐inflammatory cytokines alter metabolism and transport of
drugs affecting the clinical outcome. We used an in vivo like human 3D liver spheroid model …

First pass metabolism by phase I and phase II enzymes in the intestines and liver is a major
determinant of the oral bioavailability of many drugs. Several studies analyzed expressions …

The development of clinically effective drugs that could complement existing vaccines is
urgently needed to reduce the morbidity and mortality associated with COVID-19. Drug …