[HTML][HTML] Molecular mechanisms and therapeutic targets for diabetic kidney disease

KR Tuttle, R Agarwal, CE Alpers, GL Bakris… - Kidney international, 2022 - Elsevier
Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …

[HTML][HTML] The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs

MSA Palmnäs-Bédard, G Costabile, C Vetrani… - The American Journal of …, 2022 - Elsevier
The gut microbiota plays a fundamental role in human nutrition and metabolism and may
have direct implications for type 2 diabetes and associated preconditions. An improved …

[HTML][HTML] Identification of microbial markers across populations in early detection of colorectal cancer

Y Wu, N Jiao, R Zhu, Y Zhang, D Wu, AJ Wang… - Nature …, 2021 - nature.com
Associations between gut microbiota and colorectal cancer (CRC) have been widely
investigated. However, the replicable markers for early-stage adenoma diagnosis across …

[HTML][HTML] Gut microbiota composition in prediabetes and newly diagnosed type 2 diabetes: a systematic review of observational studies

G Letchumanan, N Abdullah, M Marlini… - Frontiers in cellular …, 2022 - frontiersin.org
Evidence of gut microbiota involvement in regulating glucose metabolism and type 2
diabetes mellitus (T2DM) progression is accumulating. The understanding of microbial …

[HTML][HTML] Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional …

N Ďásková, I Modos, M Krbcová, M Kuzma… - Nutrition & …, 2023 - nature.com
Aim The metabolic performance of the gut microbiota contributes to the onset of type 2
diabetes. However, targeted dietary interventions are limited by the highly variable inter …

[HTML][HTML] A network perspective on the ecology of gut microbiota and progression of type 2 diabetes: Linkages to keystone taxa in a Mexican cohort

DA Esquivel-Hernández, YE Martínez-López… - Frontiers in …, 2023 - frontiersin.org
Introduction The human gut microbiota (GM) is a dynamic system which ecological
interactions among the community members affect the host metabolism. Understanding the …

Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era

YE Martínez-López, DA Esquivel-Hernández… - Gut …, 2022 - Taylor & Francis
The association between the physio-pathological variables of type 2 diabetes (T2D) and gut
microbiota composition suggests a new avenue to track the disease and improve the …

[HTML][HTML] High-resolution taxonomic characterization reveals novel human microbial strains with potential as risk factors and probiotics for prediabetes and type 2 …

SA Hendricks, CA Vella, DD New, A Aunjum, M Antush… - Microorganisms, 2023 - mdpi.com
Alterations in the composition of the gut microbiota is thought to play a key role in causing
type 2 diabetes, yet is not fully understood, especially at the strain level. Here, we used long …

[HTML][HTML] Circulating nucleic acid-based biomarkers of type 2 diabetes

F Padilla-Martinez, G Wojciechowska… - International Journal of …, 2021 - mdpi.com
Type 2 diabetes (T2D) is a deficiency in how the body regulates glucose. Uncontrolled T2D
will result in chronic high blood sugar levels, eventually resulting in T2D complications …

mb-PHENIX: diffusion and supervised uniform manifold approximation for denoizing microbiota data

C Padron-Manrique, A Vázquez-Jiménez… - …, 2023 - academic.oup.com
Motivation Microbiota data encounters challenges arising from technical noise and the curse
of dimensionality, which affect the reliability of scientific findings. Furthermore, abundance …