The native environment of membrane proteins is complex and scientists have felt the need
to simplify it to reduce the number of varying parameters. However, experimental problems …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

The respiratory chain in the inner mitochondrial membrane contains three large multi‐
enzyme complexes that together establish the proton gradient for ATP synthesis, and …

Integral membrane proteins (IMPs) fulfill important physiological functions by providing cell–
environment, cell–cell and virus–host communication; nutrients intake; export of toxic …

Membrane proteins (MPs) are usually handled in aqueous solutions as protein/detergent
complexes. Detergents, however, tend to be inactivating. This situation has prompted the …

Amphipols (APols) are short amphipathic polymers that can substitute for detergents to keep
integral membrane proteins (MPs) water soluble. In this review, we discuss their structure …

This review focuses upon the application of solution NMR methods to multispan integral
membrane proteins, particularly with respect to determination of global folds by this …

Amphipols (APols) are short amphipathic polymers that can substitute for detergents at the
transmembrane surface of membrane proteins (MPs) and, thereby, keep them soluble in …

Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel, which is
expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and …

Selecting a suitable membrane-mimicking environment is of fundamental importance for the
investigation of membrane proteins. Nonconventional surfactants, such as amphipathic …