Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
[HTML][HTML] On the human taste perception: Molecular-level understanding empowered by computational methods
Background The perception of taste is a prime example of complex signal transduction at the
subcellular level, involving an intricate network of molecular machinery, which can be …
subcellular level, involving an intricate network of molecular machinery, which can be …
Cholesterol-recognition motifs in membrane proteins
The impact of cholesterol on the structure and function of membrane proteins was
recognized several decades ago, but the molecular mechanisms underlying these effects …
recognized several decades ago, but the molecular mechanisms underlying these effects …
Cholesterol in Class C GPCRs: Role, relevance, and localization
G-protein coupled receptors (GPCRs), one of the largest superfamilies of cell-surface
receptors, are heptahelical integral membrane proteins that play critical roles in virtually …
receptors, are heptahelical integral membrane proteins that play critical roles in virtually …
Cholesterol interaction motifs in G protein‐coupled receptors: Slippery hot spots?
P Sarkar, A Chattopadhyay - Wiley Interdisciplinary Reviews …, 2020 - Wiley Online Library
G protein‐coupled receptors (GPCRs) are cell membrane associated signaling hubs that
orchestrate a multitude of cellular functions upon binding to a diverse variety of extracellular …
orchestrate a multitude of cellular functions upon binding to a diverse variety of extracellular …
Exploring GPCR–lipid interactions by molecular dynamics simulations: excitements, challenges, and the way forward
D Sengupta, X Prasanna, M Mohole… - The Journal of …, 2018 - ACS Publications
Gprotein-coupled receptors (GPCRs) are seven transmembrane receptors that mediate a
large number of cellular responses and are important drug targets. One of the current …
large number of cellular responses and are important drug targets. One of the current …
Identification of two new cholesterol interaction sites on the A2A adenosine receptor
By mole, cholesterol is the most abundant component of animal cell plasma membranes.
Many membrane proteins have been shown to be functionally dependent on cholesterol …
Many membrane proteins have been shown to be functionally dependent on cholesterol …
A critical analysis of molecular mechanisms underlying membrane cholesterol sensitivity of GPCRs
G protein-coupled receptors (GPCRs) are the largest and a diverse family of proteins
involved in signal transduction across biological membranes. GPCRs mediate a wide range …
involved in signal transduction across biological membranes. GPCRs mediate a wide range …
Characterization of the binding sites for bacterial acyl homoserine lactones (AHLs) on human bitter taste receptors (T2Rs)
The 25 bitter taste receptors (T2Rs) in humans are novel players in mediating host–
pathogen responses in the airways and innate immunity. The chemosensory T2Rs are …
pathogen responses in the airways and innate immunity. The chemosensory T2Rs are …
Chemosensory bitter taste receptors (T2Rs) are activated by multiple antibiotics
A Jaggupilli, N Singh, VC De Jesus… - The FASEB …, 2019 - Wiley Online Library
Many medications including antibiotics taste bitter. The potency of these antibiotics on the 25
bitter taste receptors (T2Rs) in humans remains poorly understood. Here we characterize by …
bitter taste receptors (T2Rs) in humans remains poorly understood. Here we characterize by …