The amyloid cascade hypothesis: an updated critical review
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …
disease have created excitement and have been heralded as corroboration of the amyloid …
Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease
The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …
Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's disease
The dominant hypothesis of Alzheimer's disease (AD) aetiology, the neuropathological
guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both …
guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both …
Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology
Clinico-pathological correlation studies and positron emission tomography amyloid imaging
studies have shown that some individuals can tolerate substantial amounts of Alzheimer's …
studies have shown that some individuals can tolerate substantial amounts of Alzheimer's …
Amyloid β-protein oligomers and Alzheimer's disease
EY Hayden, DB Teplow - Alzheimer's research & therapy, 2013 - Springer
The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …
Amyloid β oligomers (AβOs) in Alzheimer's disease
B Mroczko, M Groblewska, A Litman-Zawadzka… - Journal of Neural …, 2018 - Springer
The causative role of amyloid β 1–42 (Aβ42) aggregation in the pathogenesis of Alzheimer's
disease (AD) has been under debate for over 25 years. Primarily, scientific efforts have …
disease (AD) has been under debate for over 25 years. Primarily, scientific efforts have …
The vascular hypothesis of Alzheimer's disease: a key to preclinical prediction of dementia using neuroimaging
J De La Torre - Journal of Alzheimer's Disease, 2018 - content.iospress.com
The vascular hypothesis of Alzheimer's disease (VHAD) was proposed 24 years ago from
observations made in our laboratory using aging rats subjected to chronic brain …
observations made in our laboratory using aging rats subjected to chronic brain …
Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer's disease: Current trends and future perspectives
Alzheimer's disease (AD), the most common form of dementia, is a progressive and
multifactorial neurodegenerative disorder whose primary causes are mostly unknown. Due …
multifactorial neurodegenerative disorder whose primary causes are mostly unknown. Due …
Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein
LA Gomes, SA Hipp, A Rijal Upadhaya… - Acta …, 2019 - Springer
Extracellular deposition of amyloid β-protein (Aβ) in amyloid plaques and intracellular
accumulation of abnormally phosphorylated τ-protein (p-τ) in neurofibrillary tangles (NFTs) …
accumulation of abnormally phosphorylated τ-protein (p-τ) in neurofibrillary tangles (NFTs) …
Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical …
A Rijal Upadhaya, I Kosterin, S Kumar, CAF von Arnim… - Brain, 2014 - academic.oup.com
Alzheimer's disease is characterized by the deposition of amyloid-β peptide in the brain. N-
terminal truncation resulting in the formation of AβN3pE and phosphorylation at serine 8 …
terminal truncation resulting in the formation of AβN3pE and phosphorylation at serine 8 …