Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Several of the most important discoveries in the field of membrane traffic have come from
studies of Rab GTPases by Marino Zerial and Peter Novick and their colleagues. Zerial was …

Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known
morphological phenomenon observed in mammalian cells after exposure to bacterial or viral …

Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

Summary Endocytic cargo and Rab GTPases are segregated to distinct domains of an
endosome. These domains maintain their identity until they undergo fission to traffic cargo. It …

The mechanisms of endosome biogenesis and maintenance are largely unknown. The
small GTPases Rab5 and Rab7 are key determinants of early and late endosomes …

Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking.
In yeast, two distinct PI3-kinase complexes are known: complex I (Vps34, Vps15 …

Lysosomes are composed of soluble and transmembrane proteins that are targeted to
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …

The two mannose 6-phosphate (M6P) receptors were identified because of their ability to
bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the …