Enteric nervous system development: migration, differentiation, and disease

JI Lake, RO Heuckeroth - American Journal of Physiology …, 2013 - journals.physiology.org
The enteric nervous system (ENS) provides the intrinsic innervation of the bowel and is the
most neurochemically diverse branch of the peripheral nervous system, consisting of two …

[HTML][HTML] The enteric nervous system

V Sasselli, V Pachnis, AJ Burns - Developmental biology, 2012 - Elsevier
The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract,
consists of numerous types of neurons, and glial cells, that are distributed in two …

Development and developmental disorders of the enteric nervous system

F Obermayr, R Hotta, H Enomoto… - Nature reviews …, 2013 - nature.com
The enteric nervous system (ENS) arises from neural crest-derived cells that migrate into
and along the gut, leading to the formation of a complex network of neurons and glial cells …

Building a second brain in the bowel

M Avetisyan, EM Schill… - The Journal of clinical …, 2015 - Am Soc Clin Investig
The enteric nervous system (ENS) is sometimes called the “second brain” because of the
diversity of neuronal cell types and complex, integrated circuits that permit the ENS to …

[HTML][HTML] The enteric nervous system undergoes significant chemical and synaptic maturation during adolescence in mice

P Parathan, Y Wang, AJL Leembruggen… - Developmental …, 2020 - Elsevier
Adolescence is a critical period of development. It is very likely that there is significant
maturation of the enteric nervous system (ENS) of the gut during this stage of life, especially …

[HTML][HTML] Enteric nervous system assembly: Functional integration within the developing gut

MM Hao, JPP Foong, JC Bornstein, ZL Li… - Developmental …, 2016 - Elsevier
Co-ordinated gastrointestinal function is the result of integrated communication between the
enteric nervous system (ENS) and “effector” cells in the gastrointestinal tract. Unlike smooth …

Birthdating of myenteric neuron subtypes in the small intestine of the mouse

AJ Bergner, LA Stamp, DG Gonsalvez… - Journal of …, 2014 - Wiley Online Library
There are many different types of enteric neurons. Previous studies have identified the time
at which some enteric neuron subtypes are born (exit the cell cycle) in the mouse, but the …

Colonizing while migrating: how do individual enteric neural crest cells behave?

HM Young, AJ Bergner, MJ Simpson, SJ McKeown… - BMC biology, 2014 - Springer
Background Directed cell migration is essential for normal development. In most of the
migratory cell populations that have been analyzed in detail to date, all of the cells migrate …

[HTML][HTML] Gene-environment interactions and the enteric nervous system: Neural plasticity and Hirschsprung disease prevention

RO Heuckeroth, KH Schäfer - Developmental biology, 2016 - Elsevier
Intestinal function is primarily controlled by an intrinsic nervous system of the bowel called
the enteric nervous system (ENS). The cells of the ENS are neural crest derivatives that …

A novel enteric neuron–glia coculture system reveals the role of glia in neuronal development

C Le Berre‐Scoul, J Chevalier… - The Journal of …, 2017 - Wiley Online Library
Key points Unlike astrocytes in the brain, the potential role of enteric glial cells (EGCs) in the
formation of the enteric neuronal circuit is currently unknown. To examine the role of EGCs …