Retinoic acid receptors: from molecular mechanisms to cancer therapy
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
Retinoids in cancer therapy and chemoprevention: promise meets resistance
SJ Freemantle, MJ Spinella, E Dmitrovsky - Oncogene, 2003 - nature.com
Retinoids (natural and synthetic derivatives of vitamin A) signal potent differentiation and
growth-suppressive effects in diverse normal, premalignant, and malignant cells. A strong …
growth-suppressive effects in diverse normal, premalignant, and malignant cells. A strong …
Sequestration and inhibition of Daxx-mediated transcriptional repression by PML
H Li, C Leo, J Zhu, X Wu, J O'Neil, EJ Park… - Molecular and cellular …, 2000 - Taylor & Francis
PML fuses with retinoic acid receptor α (RARα) in the t (15; 17) translocation that causes
acute promyelocytic leukemia (APL). In addition to localizing diffusely throughout the …
acute promyelocytic leukemia (APL). In addition to localizing diffusely throughout the …
Retinoic acid receptors and cancers
DR Soprano, P Qin, KJ Soprano - Annu. Rev. Nutr., 2004 - annualreviews.org
▪ Abstract Studies utilizing experimental animals, epidemiological approaches, cellular
models, and clinical trials all provide evidence that retinoic acid and some of its synthetic …
models, and clinical trials all provide evidence that retinoic acid and some of its synthetic …
Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML-and PLZF-RARα underlie molecular pathogenesis and treatment of acute …
F Guidez, S Ivins, J Zhu… - Blood, The Journal …, 1998 - ashpublications.org
Typical acute promyelocytic leukemia (APL) is associated with expression of the PML-RARα
fusion protein and responsiveness to treatment with all-trans retinoic acid (ATRA). A rare, but …
fusion protein and responsiveness to treatment with all-trans retinoic acid (ATRA). A rare, but …
Mechanisms involved in the induced differentiation of leukemia cells
Despite the remarkable progress achieved in the treatment of leukemias over the last
several years, many problems (multidrug resistance [MDR], cellular heterogeneity …
several years, many problems (multidrug resistance [MDR], cellular heterogeneity …
Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers
Abstract The t (15; 17) chromosomal translocation in acute promyelocytic leukemia (APL)
generates the PML-RARα fusion protein. The recruitment of nuclear receptor corepressor …
generates the PML-RARα fusion protein. The recruitment of nuclear receptor corepressor …
Genetic diagnosis and molecular monitoring in the management of acute promyelocytic leukemia
DESPITE ITS well-known sensitivity to anthracyclines, 1-5 acute promyelocytic leukemia
(APL) was catalogued until the late 1980s as one of the most rapidly fatal human tumors …
(APL) was catalogued until the late 1980s as one of the most rapidly fatal human tumors …
ER stress and unfolded protein response in leukemia: friend, foe, or both?
K Féral, M Jaud, C Philippe, D Di Bella, S Pyronnet… - Biomolecules, 2021 - mdpi.com
The unfolded protein response (UPR) is an evolutionarily conserved adaptive signaling
pathway triggered by a stress of the endoplasmic reticulum (ER) lumen compartment, which …
pathway triggered by a stress of the endoplasmic reticulum (ER) lumen compartment, which …