Molecular and enzoinformatics perspectives of targeting Polo-like kinase 1 in cancer therapy
Cancer is a disease that has been the focus of scientific research and discovery and
continues to remain so. Polo-like kinases (PLKs) are basically serine/threonine kinase …
continues to remain so. Polo-like kinases (PLKs) are basically serine/threonine kinase …
A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key
L Pintard, V Archambault - Open Biology, 2018 - royalsocietypublishing.org
The Polo kinase is an essential regulator of cell division. Its ability to regulate multiple events
at distinct subcellular locations and times during mitosis is remarkable. In the last few years …
at distinct subcellular locations and times during mitosis is remarkable. In the last few years …
Discovery of targeted covalent natural products against PLK1 by herb-based screening
H Liang, H Liu, Y Kuang, L Chen, M Ye… - Journal of chemical …, 2020 - ACS Publications
Natural products (NPs) are a rich source of drug discovery, and some of them act by
covalently binding to the targets. Recently, targeted covalent natural product (TCNP) design …
covalently binding to the targets. Recently, targeted covalent natural product (TCNP) design …
Oxcarbazepine induces mitotic catastrophe and apoptosis in NRK-52E proximal tubular cells
M Ota, T Funakoshi, T Aki, K Unuma, K Uemura - Toxicology Letters, 2021 - Elsevier
Certain medicines including anticancer drugs, NSAIDs and antiepileptic drugs are known to
cause drug-induced nephropathy. For example, antiepileptic drugs such as carbamazepine …
cause drug-induced nephropathy. For example, antiepileptic drugs such as carbamazepine …
A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia
Y Chen, X Xie, A Wu, L Wang, Y Hu, H Zhang… - Journal of Experimental & …, 2018 - Springer
Background Oncogenic roles of epidermal growth factor receptor pathway substrate no. 8
(EPS8) have been widely reported in various tumors, making targeting of EPS8 an …
(EPS8) have been widely reported in various tumors, making targeting of EPS8 an …
Plk1 interacts with RNF2 and promotes its ubiquitin‑dependent degradation
R An, L Cheng, L Chen, J Du - Oncology Reports, 2018 - spandidos-publications.com
Ring finger protein 2 (RNF2), also known as RING2 or RING1B, displays oncogenic
functions in different types of cancers, yet, the function of RNF2 during mitosis has not been …
functions in different types of cancers, yet, the function of RNF2 during mitosis has not been …