Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model

Z Han, JS Rao, L Gangwar, BE Namsrai… - Nature …, 2023 - nature.com
Banking cryopreserved organs could transform transplantation into a planned procedure
that more equitably reaches patients regardless of geographical and time constraints …

Cryopreservation in the era of cell therapy: revisiting fundamental concepts to enable future technologies

B Bai, C Xue, Y Wen, J Lim, Z Le… - Advanced Functional …, 2023 - Wiley Online Library
Cryopreservation strives to maximize the viability and biofunctionality of cells and tissues by
cooling them to a subzero temperature to facilitate storage and delivery. This technology has …

Vitrification and nanowarming of kidneys

A Sharma, JS Rao, Z Han, L Gangwar… - Advanced …, 2021 - Wiley Online Library
Vitrification can dramatically increase the storage of viable biomaterials in the cryogenic
state for years. Unfortunately, vitrified systems≥ 3 mL like large tissues and organs, cannot …

Rapid joule heating improves vitrification based cryopreservation

L Zhan, Z Han, Q Shao, ML Etheridge, T Hays… - Nature …, 2022 - nature.com
Cryopreservation by vitrification has far-reaching implications. However, rewarming
techniques that are rapid and scalable (both in throughput and biosystem size) for low …

Vitrification and rewarming of magnetic nanoparticle‐loaded rat hearts

Z Gao, B Namsrai, Z Han, P Joshi… - Advanced materials …, 2022 - Wiley Online Library
To extend the preservation of donor hearts beyond the current 4–6 h, this paper explores
heart cryopreservation by vitrification—cryogenic storage in a glass‐like state. While organ …

Cryopreservation of whole rat livers by vitrification and nanowarming

A Sharma, CY Lee, BE Namsrai, Z Han… - Annals of biomedical …, 2023 - Springer
Liver cryopreservation has the potential to enable indefinite organ banking. This study
investigated vitrification—the ice-free cryopreservation of livers in a glass-like state—as a …

Magnetic nanoparticles for nanowarming: seeking a fine balance between heating performance and biocompatibility

Z Ye, S Liu, Y Yin - Materials Chemistry Frontiers, 2023 - pubs.rsc.org
Regenerative medicine has the potential to revolutionize healthcare by providing transplant
options for patients suffering from tissue disease or organ failure. Cryopreservation offers a …

Cryopreservation of organoids: Strategies, innovation, and future prospects

H Han, T Zhan, N Guo, M Cui, Y Xu - Biotechnology Journal, 2024 - Wiley Online Library
Organoid technology has demonstrated unique advantages in multidisciplinary fields such
as disease research, tumor drug sensitivity, clinical immunity, drug toxicology, and …

Engineering Magnetic Nanoclusters for Highly Efficient Heating in Radio-Frequency Nanowarming

Z Ye, Y Tai, Z Han, S Liu, ML Etheridge… - Nano Letters, 2024 - ACS Publications
Effective thawing of cryopreserved samples requires rapid and uniform heating. This is
achievable through nanowarming, an approach that heats magnetic nanoparticles by using …

Combining cooling enhancement and trehalose dehydration to enable scalable volume cryopreservation of red blood cells with low concentration of glycerol

L Shen, X Qin, M Wang, D Gao… - Advanced …, 2022 - Wiley Online Library
Enhancing the cooling rate is often an alternative to increasing concentrations of
cryoprotectants to inhibit harmful ice growth during freezing. Processing cell suspensions as …