Comprehensive review of targeted therapy for colorectal cancer
YH Xie, YX Chen, JY Fang - Signal transduction and targeted therapy, 2020 - nature.com
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …
ErbB receptors and cancer
Z Wang - ErbB receptor signaling: methods and protocols, 2017 - Springer
The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
JL Hsu, MC Hung - Cancer and Metastasis Reviews, 2016 - Springer
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
Molecular targeting therapy against EGFR family in breast cancer: progress and future potentials
AE Maennling, MK Tur, M Niebert, T Klockenbring… - Cancers, 2019 - mdpi.com
The epidermal growth factor receptor (EGFR) family contains four transmembrane tyrosine
kinases (EGFR1/ErbB1, Her2/ErbB2, Her3/ErbB3 and Her4/ErbB4) and 13 secreted …
kinases (EGFR1/ErbB1, Her2/ErbB2, Her3/ErbB3 and Her4/ErbB4) and 13 secreted …
The many substrates of presenilin/γ-secretase
A Haapasalo, DM Kovacs - Journal of Alzheimer's disease, 2011 - content.iospress.com
The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …
The yin and yang of ERBB4: tumor suppressor and oncoprotein
Abstract ERBB4 (HER4) is a member of the ERBB family of receptor tyrosine kinases, a
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …
Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome
MD Begnami, E Fukuda, JHTG Fregnani… - Journal of clinical …, 2011 - ascopubs.org
Purpose The human epidermal growth factor receptor (HER) family consists of four
members: ErbB-1 (HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4). These …
members: ErbB-1 (HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4). These …
Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival
HW Lo, MC Hung - British journal of cancer, 2006 - nature.com
Emerging evidences suggest the existence of a new mode of epidermal growth factor
receptor (EGFR) signalling pathway in which activated EGFR undergoes nuclear …
receptor (EGFR) signalling pathway in which activated EGFR undergoes nuclear …
A review of HER4 (ErbB4) kinase, its impact on cancer, and its inhibitors
MI El-Gamal, NH Mewafi, NE Abdelmotteleb… - Molecules, 2021 - mdpi.com
HER4 is a receptor tyrosine kinase that is required for the evolution of normal body systems
such as cardiovascular, nervous, and endocrine systems, especially the mammary glands. It …
such as cardiovascular, nervous, and endocrine systems, especially the mammary glands. It …
Therapeutic potential of targeting the SUMO pathway in cancer
A Kukkula, VK Ojala, LM Mendez, L Sistonen… - Cancers, 2021 - mdpi.com
Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark
properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery …
properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery …